Home / PDA Technical Glossary

PDA Technical Glossary

PDA Technical Reports are highly valued membership benefits because they offer expert guidance and opinions on important scientific and regulatory topics and are used as essential references by industry and regulatory authorities around the world. These reports include terms which explain the material and enhance the reader’s understanding.

The database presented here includes the glossary terms from all current technical reports. The database is searchable by keyword, topic, or by technical report. Each definition provided includes a link to the source technical report within the PDA Technical Report Portal.

(Please select "All" to restart a filtered Search)

Refine Results

Filter By GlossaryTrNumber

Filter By GlossaryTrKeyword

TR 71: Emerging Methods for Virus Detection

Latent Virus

Latency is the ability of a virus to be dormant (latent) within a cell (for example, genetic episomes; provirus). Under certain conditions the virus may become active and produce particles. (TR71)

Source:

Hemagglutination

A clumping together or agglutination of red blood cells. In the context of this Technical Report hemagglutination indicates presence of virus that binds to erythrocytes. (TR47) The clumping of red blood cells by binding to virus particles. The hemagglutination reaction is used in cell-based in vitro assays as an end point for virus detection. (TR71)

Source:

Hemadsorption

Adherence of red blood cells to virus-specific antigens on the surface of infected cells. In cellbased in vitro assays the reaction is used as an end point for virus detection. (TR47) (TR71)

Source:

Indicator Cells

Cell lines that are used in in vitro assays to detect the presence of viral agents. (TR71)

Source:

Endogenous Virus

A virus that pre-exists in the genome of the cell substrate. (TR71) A virus that integrates into the genome of the cell substrate. (TR83)

Source:

De Novo Sequence Assembly

Assembly of short reads of a sequence to generate a contiguous sequence (contig). (TR71)

Source:

Biological Medicinal Product

A product (therapeutic or prophylactic) for human use that has been manufactured in or from a biological source. Examples include recombinant therapeutic proteins or vaccines. Biological medicinal products are also referred to as: biological medicines, biological products, biologics and biologic drugs. (TR 71)

Source:

BLAST

Basic Local Alignment Search Tool; a bioinformatics algorithm for the comparison of sequence data (e.g., translated amino acids [tBLASTx], proteins [BLASTx], or nucleotides [BLASTn]). (TR 71)

Source:

Cell Substrate

The host cells that are used to propagate or detect viruses. (TR 47) Cells used for the manufacture of a biological medicinal product. (TR 71) (TR 83)

Source: