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PDA Technical Glossary

PDA Technical Reports are highly valued membership benefits because they offer expert guidance and opinions on important scientific and regulatory topics and are used as essential references by industry and regulatory authorities around the world. These reports include terms which explain the material and enhance the reader’s understanding.

The database presented here includes the glossary terms from all current technical reports. The database is searchable by keyword, topic, or by technical report. Each definition provided includes a link to the source technical report within the PDA Technical Report Portal.

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TR 75: Mycoplasma Filter Rating Method

Titer Reduction (TR)

A measure of the degree to which a particular filter removes a microorganism under specified test conditions. Calculated as the ratio of the total number of microorganisms used to challenge the filter divided by the total number of microorganisms that passed through the filter. (TR75)

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Psid

Pound-force per square-inch differential is the difference in pressure; for example, the pressure differential between the upstream (influent) and downstream (effluent) sides of a filter. (TR75)

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Positive Control Filter Membrane (Penetration Control)

A control filter membrane with a larger pore size rating than the test filter and used to demonstrate the penetrative ability of the test microorganism. Penetration of this filter by at least one CFU is required to validate a test. (TR75)

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Mycoplasma Reduction Filter

A sterilizing grade filter that also provides a log reduction value (or a titer reduction value) for a specified test mycoplasma according to the PDA Mycoplasma Consensus Method. (TR75)

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Kilopascal (kPa)

The International System of Units derived unit of pressure. (TR75)

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Challenge Volume

The volume of challenge fluid applied to the test filter. (TR75)

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Challenge Concentration

The concentration in Colony Forming Units/mL of the test microorganism in the challenge fluid. (TR75)

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Challenge Level

The concentration of the test microorganism applied to the test filter (per centimeter squared) or the total number of cells applied to the test filter at the completion of the challenge. (TR75)

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Acholeplasma laidlawii

A. laidlawii is a mycoplasma in class Mollicutes and order Acholeplasmatales. (TR75)

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