PDA Letter Article

Glass Breakage in Pharmaceutical Packaging

by Carina Bronnbauer, PhD, SCHOTT

Tube and vial (002)

Highly Welcome or Utmost Feared?

Thanks to low extractable/leachable profiles, small diffusion coefficients and high transparency, glass reigns as the undisputed material of choice for parenteral packaging. For a long time, the only major drawback of glass was believed to be its inherent breakage risk. This has not changed: recent concerns about breakage have prompted some parenteral manufacturers to take another look.