Michael J Hantman, PhD Charles River Laboratories

Michael J. Hantman, Associate Director of Methods Development and Validation for Charles River, received his Ph.D. from Temple University School of Medicine working on genetic mapping and pathogenicity of Streptococcus mutans, the main cause of dental caries.

Postdoctoral fellowships at Harvard Medical School, Massachusetts General Hospital, and at the University of Washington focused on vaccine development and host-pathogen interactions, using recombinant, attenuated salmonella strains expressing heterologous genes to stimulate immune pathways.

Over the past 19 years, Michael and his team have developed and validated over 250 methods used for the detection/quantitation of adventitious agents in biopharmaceuticals as well as for characterization of substrates used in the production of biopharmaceuticals, including quantitative PCR assays for specific and broad-range targets, residual HCD/sizing, and copy number.