Glossary Terms (Simple List)
-
Virus (Specific Model Virus)
Virus that is closely related to the known or suspected virus (same genus or family), having similar physical and chemical properties as those of the observed or suspected virus. (TR47)
-
Virus Preparation
According to the mode of preparation the following terms are used:
Crude Virus Preparation: A virus preparation that has undergone minimal processing post propagation. The virus is usually separated from cells which are lysed as the result of virus replication or are freezed/thawed in one or several cycles to release the virus from infected cells. The preparation is typically purified from cell debris by low speed centrifugation.
Purified Virus Preparation: A virus that has undergone purification process by one or more techniques, such as density ultracentrifugation, chromatography or membrane adsorber. The purity of the virus preparation varies depending on the purification technique and should be characterized by appropriate analytical methods. (TR47) -
Virus Production Lot
A virus preparation that is used directly in a clearance study. It can be crude or purified. Typically a large volume is produced, tested and qualified. This volume is divided into multiple aliquots for individual clearance studies. (TR47)
-
Virus Removal
Physical separation of virus particles from the intended product. (TR41)
-
Virus Seed
An initial virus stock produced after a new virus is introduced into a laboratory. Its purpose is to create a Master Virus Bank. (MVB) (TR47)
-
Viscosity
A solution property that is a measure of the fluid’s resistance to deformation when acted upon by shear forces. (TR15)
-
Visible fiber
A fiber-like particle with an aspect ratio ≥5 and a length >300 µm. (TR85)
-
Visible particle
A particle with an aspect ratio of <5 and a length >100 µm. (TR85)
-
Visible Particle Range
Particulate matter sized above the visible particle 70% probability of detection threshold are considered in the visible range, typically >100-150 μm. (TR79)
-
Visually Clean
Absence of materials that would adulterate a product when inspected with the eyes. (TR70)