Glossary Terms (Simple List)
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Clinician
A physician, psychiatrist, etc., who specializes in clinical work as opposed to one engaged in laboratory or experimental studies. (TR58)
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Cloning
The process of creating identical copies of DNA fragments or a homogeneous preparation of cells, viruses or other organisms. (TR47)
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Closed System
An isolated system that has no interaction with its external environment, preventing contamination and release of the material contained.(TR28) (TR 66)
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Coefficient of Determination (r²)
A measure of the proportion of the variation of one variable determined by the variation of the other. (TR57)
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Cold Chain
A temperature- and time-controlled supply chain for products (e.g., refrigerated products typically have a temperature storage range of 2 °C to 8 °C). (TR58)
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Cold Chain Tolerance Groups
This concept expands the “normal” definition of cold chain to include all products that need to be stored below 250C and also introduces the ancillary terms “ambient temperatures” and “controlled ambient”. (TR46)
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Cold Spot
The location within an SIP system that achieves the lowest process lethality (F0) during a SIP process. Note: When lethality values are not available or not applicable (e.g., a sanitization process operating at less than 100 °C) the cold spot is the location with the lowest temperature profile during the SIP cycle. (TR61)
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Colloid
A mixture with properties between those of a solution and a fine suspension. (TR45)
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Colonization (Microbial)
Growth (division) of adherent microorganisms on a surface (TR 69)
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Colony Forming Unit (CFU)
One or more microorganisms that produce a visible, discrete growth entity on a semi-solid, agar-based microbiological medium. (TR22) (TR62)
Visible outcome of growth of microorganisms arising from a single or multiple cells. (TR28)
A single microorganism or an aggregate of many that forms a single discrete colony on solid agar media after suitable incubation. Colony forming units are used for bacterial titer (total bacteria load in a sample) determination on solid media. (TR50) (TR75)