Glossary Terms (Simple List)
-
Limit Test
A quantitative test designed to give a positive/negative response. Ideally, a limit test has a high degree of specificity and a low limit of detection. (TR50).
-
Limit, Detection (DL)
The lowest amount of analyte in a sample that can be detected but not necessarily quantitated as an exact value by an individual analytical procedure. [Synonym: Limit of detection (LOD)] (TR57)
-
Limit, Quantitation (QL)
The lowest amount of analyte is a sample that can be quantitatively determined with suitable precision and accuracy by an individual analytical procedure. [Synonym: Limit of quantitation (LOQ)] (TR57)
-
Limiting Dilution
In the context of this Technical Report the limiting dilution technique is used for virus cloning. The virus suspension is diluted until virus is no longer detectable. The dilution immediately before the dilution where infection of cells is no longer detectable is considered to contain only one virus particle or a very low number of virus particles. (TR47)
-
Limulus Amebocyte Lysate (LAL) Test
Endotoxin detection and quantitation can be accomplished at high sensitivity and specificity using reagents manufactured from Limulus Amebocyte Lysate, a biological reagent prepared from horseshoe crabs and offered in a variety of formulations. (TR45)
-
Limulus Amoebocyte Lysate (LAL) Test
A biologically based assay for the detection and quantitation of bacterial endotoxin. (TR69)
-
Linearity
The ability to elicit results that are proportional to the concentration of microorganisms present in the sample within a given range, where accuracy and precision are demonstrated. (TR33)
The linearity of an analytical procedure is its ability (within a given range) to obtain test results that are directly proportional to the concentration (amount) of analyte in the sample. (TR57)
-
Lipopolysaccharide
A component of the cell wall of Gram-negative bacteria.(TR3)
Component of the outer cell wall of Gram-negative bacteria that is pyrogenic. (TR69)(TR82)
-
Liquid Load
A load consisting of closed containers of aqueous liquids. The sterilization of the container contents is achieved through transfer of energy through the container into the aqueous liquid. (TR01) (TR30) (TR48)
-
Load Density
The amount of target molecules per volume of resin (e.g., gram protein per milliliter resin). (TR14)